Vetrix® Bibliography: Listed publications about Vetrix® Small Intestinal Submucosa (SIS) ECM Biochemistry and it’s applications.


Vetrix® BioSIS ECM Biochemistry Vetrix® Avian Surgery


Badylak, S.F., D.O. Freytes, and T.W. Gilbert. 2009. Extracellular Matrix as a Biological Scaffold Material: Structure and Function. Acta Biomater. 5:1-13.


Beattie, A.J., T.W. Gilbert, J.P. Guyot, A.J. Yates, and S.F. Badylak. 2009. Chemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds. Tissue Eng Part A. 15:1119-1125.


Valentin, J.E., A.M. Stewart-Akers, T.W. Gilbert, and S.F. Badylak. 2009. Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds. Tissue Eng Part A. 15:1687-1694.


Badylak. S.F., and T.W. Gilbert. 2008. Immune Response to Biologic Scaffold Materials. Semin Immunol. 20:109-116.


Research on SIS Extracellular Matrix for Veterinary Applications



Holt, T.M., Mann, F.A. 2003. Carbon Dioxide Laser Resection of a Distal Carpal Pilomatricoma and Wound Closure Using Swing Intestinal Submucosa in a Dog. Journal of American Animal Hospital Association. 2002;39:499-505.


Werier J, Ferguson P, Bell R, Hill R. 2006. Model of Radiation-Impaired Healing of a Deep Excisional Wound. Wound Repair and Regeneration. 2006; 14:498-505.



Chen MK, Beierle EA. 2004. Animal models for intestinal tissue engineering. Biomaterials. 2004;25:1675-1681.


Chen MK, Badylak SF. 2001. Small Bowel Tissue Engineering Using Small Intestinal Submucosa as a Scaffold. Journal of Surgical Reseach. 2001; 99:352-358.


de la Fuente SG, Gottfried MR, Lawson. 2003. Evaluation of Porcine-Derived Small Intestinal Submucosa as a Biodegradable Graft for Gastrointestinal Healing. Journal of Gastrointestinal Surgery. 2003; 7:96-101.


Demirbilek S, Kanmaz T, Ozardali I, Edali. 2003. Using Porcine Small Intestinal Submucosa in Intestinal Regeneration. Pediatric Surgery International. 2003; 19:588-592.


Desai KM, Diaz S, Dorward IG, Winslow. 2006. Histologic Results 1 Year After Bioprosthetic Repair of Paraesophageal Hernia in a Canine Model. Surgical Endoscopy. 2006;20:1693-


Gubbels SP, Richardson M, Trune D. 2006. Tracheal Reconstruction With Porcine Small Intestine Submucosa in a Rabbit Model. Otolaryngology and Head and Neck Surgery. 2006; 134:1028-


Konstantinovic ML, Lagae P, Zheng F. 2005. Comparison of Host Response to Polypropylene and Non-Cross-Linked Porcine Small Intestine Serosal-Derived Collagen Implants in a Rat Model. British Journal of Obstetrics and Gynecology. 2005; 112:1554-


Pinheiro JS, Correa JL, Cohen RV. 2006. Staple Line Reinforcement With New Biomaterial Increased Burst Strength Pressure: An Animal Study. Surgery for Obesity and Related Diseases. 2006; 2:397-399.


Rosen M, Ponsky J, Petras R, Fanning A. 2002. Small Intestinal Submucosa as a Bioscaffold for Biliary Tract Regeneration. Surgery. 2002; 194:541-543.


Souza Filho ZA, Greca FH, Rocha SL. 2005. Porcine Submucosa Graft for the Treatment of Duodenal Injuries in Dogs. Acta Chirgica Brasiliera. 2005; 20:394-398.


Stoll MR, Cook JL, Pope ER, Carson WL. 2002. The Use of Small Intestinal Submucosa as a Biomaterial for Perineal Herniorrhapy in the Dog. Veterinary Surgery. 2002;31:379-390.


Wood JD, Simmons-Byrd A, Spievack AR. 2005. Use of particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs. Journal of the American Veterinary Medical Association. 2005; 226:1095-

General Surgery


Ko R, Kazacos EA, Snyder S, Ernst DM. 2006. Tensile Strength Comparison of Small Intestinal Submucosa Body Wall Repair. Journal of Surgical Research. 2006; 135:9-17.



Bussieres M, Krohne SG, Stiles J. 2004. The use of porcine small intestinal submucosa for the repair of full-thickness corneal defects in dogs, cats and horses. Veterinary Ophthalmology. 2004; 7:352-359.


Featherstone HJ, Sansom J, Heinrich CL. 2001. The use of porcine small intestinal submucosa in ten cases of feline corneal disease. Veterinary Ophthalmology. 2001; 4:147-153.


Vanore M, Chahory S, Payen G, Clerc B. 2007. Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats. Journal of Veterinary Medicine. 2003;33:101-106.


Vetrix® SIS ECM is the most widely researched and proven extracellular matrix on the market. To learn more about the biochemistry or the various applications for which it has been proven successful see our additional resource page.