Vetrix® BioSIS For Chronic Wounds

Vetrix® BioSIS is derived from porcine small intestinal submucosa (SIS). With over 20 years of manufacturing experience, the same product is widely used in the human field of medicine for a variety of uses. One such use is trauma and wound care. Oasis® Wound Dressing was used in a series of burn treatment cases published in the International Journal of Burns and Trauma.

Vetrix® BioSIS ECM is a perfect solution for chronic wounds and trauma in veterinary medicine.  The article published in the International Journal of Burns and Trauma gives expansive detail into the biochemical and biomechanics characterization of BioSIS, and why it is the perfect solution for wound care in animals. Remember, when you are faced with trauma cases, burns or chronic wounds, use Vetrix BioSIS to not only prevent scarring, but actually regenerate new organized tissue.

Biochemical and biomechanics characterization of porcine small intestinal submucosa (SIS): a mini review

Lei Shi, Vincent Ronfraid

Abstract:

Porcine small intestinal submucosa (SIS [Oasis®]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)—endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.

View Full Length Publication- Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review

 

Vetrix® LLC is the leading provider of veterinary extracellular matrix (ECM) technologies, providing an environment for cells to naturally regenerate via an acelluar graft. Vetrix®, which is derived from porcine small intestinal submucosa (SIS), can be surgically implanted on any tissue area in need of repair, including the skin, tendons and ligaments, cartilage, muscles, bones and more. The product repairs and regenerates cells in damaged areas by mimicking the natural functionality of the surrounding area, healing wounds quicker than ever.

 

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Order Vetrix® BioSIS

See our product page for clinical protocol and additional product information.

Vetrix and Bay Area Equestrian Vet Camp

Like no other equine veterinary camp, Bay Area Equestrian incorporates STEM (science, technology, engineering, and math) for equestrians. This year, BAE Vet Camp will host expert mentors and exclusive workshops at UC Davis, School of Veterinary Medicine, UC Berkeley, Stanford University, Peninsula Equine Medical Center, Borges Ranch, and MORE. Here, students will earn practical and clinical veterinary experience, and hours working side-by-side with veterinary practitioners, all while helping rehabilitate rescue horses.

We at Vetrix proudly support BAE Vet Camp, and hope to further educate students and practitioners about the regenerative healing capabilities of Extracellular Matrix technology. You can learn more about BAE Vet Camp, and the wonderful organization that is Bay Area Equestrian at www.baeclub.org.

Vetrix LLC is the leading provider of veterinary extracellular matrix (ECM) technologies, providing an environment for cells to naturally regenerate via an acelluar graft. Vetrix, which is derived from porcine small intestinal submucosa (SIS), can be surgically implanted on any tissue area in need of repair, including the skin, tendons and ligaments, cartilage, muscles, bones and more. The product repairs and regenerates cells in damaged areas by mimicking the natural functionality of the surrounding area, healing wounds quicker than ever.

 


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Vetrix BioSIS for Avian Wound Care

Vetrix BioSIS was used in a series of avian wound care cases published in the Journal of Avian Medicine and Surgery .

Vetrix BioSIS ECM is a perfect solution for soft tissue repair.  A perfect example is the avian wound care publication submitted several years ago by Dr. Stephen Divers of University of Georgia School of Veterinary Medicine. Remember, when you are faced with a soft tissue injury, use Vetrix BioSIS to not only prevent scarring, but actually regenerate new organized tissue. Just like in Dr. Divers’ study, Vetrix BioSIS is scientifically proven to regenerate a variety of host tissue.

Xenogeneic Grafts Using Porcine Small Intestinal Submucosa in the Repair of Skin Defects in 4 Birds

Stephen J. Hernandez-Divers, B Vet Med, Dipl Zoo Med, MRCVS, and Sonia M. Hernandez-Divers, DVM, Dipl ACZM

Abstract: Trauma and skin defects are common presentations in companion and wild birds. Two barn owls (Tyto alba), an umbrella cockatoo (Cacatua alba), and an American crow (Corvus brachyrhynchos) were presented for varied skin wounds. Porcine small intestinal submucosa was used as a xenogeneic graft to repair wound defects in each bird. The wounds healed within 6 weeks in all 4 birds, with less intensive wound management than that required for healing by second intention. All birds returned to normal function.

View Full Length Publication- Hernandez_JAvianMed_2003

 

Vetrix LLC is the leading provider of veterinary extracellular matrix (ECM) technologies, providing an environment for cells to naturally regenerate via an acelluar graft. Vetrix, which is derived from porcine small intestinal submucosa (SIS), can be surgically implanted on any tissue area in need of repair, including the skin, tendons and ligaments, cartilage, muscles, bones and more. The product repairs and regenerates cells in damaged areas by mimicking the natural functionality of the surrounding area, healing wounds quicker than ever.

 

 

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Feline Surgical Case Report Using Vetrix SIS

Vetrix BioSIS was used in interesting feline surgical case report performed at University of Zurich.

Vetrix BioSIS ECM is a perfect solution for soft tissue repair. We are constant learning of interesting procedures where Vetrix SIS was used to repair a defect. A perfect example is the feline case report submitted several years ago by Dr. Angelo Andreoni and Dr. Katja Voss from our good friends at the University of Zurich. Remember, when you are faced with a soft tissue injury, use Vetrix BioSIS to not only prevent scarring, but actually regenerate new organized tissue. Just like in Dr. Andreoni and Dr. Voss’s study, Vetrix BioSIS is scientifically proven to regenerate a variety of host tissue

CASE REPORT: Reconstruction of a large diaphragmatic defect in a kitten using small intestinal submucosa (SIS)

Angelo A. Andreoni, Dr Med Vet, Katja Voss, Dr. Med Vet Diplomate ECVS

Abstract:

A double-layer sheet of small intestinal submucosa (SIS) was used to reconstruct a large chronic diaphragmatic defect in a 4-month-old kitten. The SIS graft was easy to use, postoperative recovery was uneventful, no side effects of the SIS implant were observed, and the SIS graft resulted in restoration of normal clinical function while allowing growth of the kitten without restriction of chest wall development. Herniation of fat through the caval hiatus was diagnosed 29 months postoperatively on a CT scan. The cat was free of clinical signs.

View Full Length Case Report- Andreoni_JFelineMed_2009 [epub]

 

 Vetrix LLC is the leading provider of veterinary extracellular matrix (ECM) technologies, providing an environment for cells to naturally regenerate via an acelluar graft. Vetrix, which is derived from porcine small intestinal submucosa (SIS), can be surgically implanted on any tissue area in need of repair, including the skin, tendons and ligaments, cartilage, muscles, bones and more. The product repairs and regenerates cells in damaged areas by mimicking the natural functionality of the surrounding area, healing wounds quicker than ever.

 

 

 

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