Vetrix® BioSIS For Chronic Wounds

Vetrix® BioSIS is derived from porcine small intestinal submucosa (SIS). With over 20 years of manufacturing experience, the same product is widely used in the human field of medicine for a variety of uses. One such use is trauma and wound care. Oasis® Wound Dressing was used in a series of burn treatment cases published in the International Journal of Burns and Trauma.

Vetrix® BioSIS ECM is a perfect solution for chronic wounds and trauma in veterinary medicine.  The article published in the International Journal of Burns and Trauma gives expansive detail into the biochemical and biomechanics characterization of BioSIS, and why it is the perfect solution for wound care in animals. Remember, when you are faced with trauma cases, burns or chronic wounds, use Vetrix BioSIS to not only prevent scarring, but actually regenerate new organized tissue.

Biochemical and biomechanics characterization of porcine small intestinal submucosa (SIS): a mini review

Lei Shi, Vincent Ronfraid


Porcine small intestinal submucosa (SIS [Oasis®]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)—endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.

View Full Length Publication- Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review


Vetrix® LLC is the leading provider of veterinary extracellular matrix (ECM) technologies, providing an environment for cells to naturally regenerate via an acelluar graft. Vetrix®, which is derived from porcine small intestinal submucosa (SIS), can be surgically implanted on any tissue area in need of repair, including the skin, tendons and ligaments, cartilage, muscles, bones and more. The product repairs and regenerates cells in damaged areas by mimicking the natural functionality of the surrounding area, healing wounds quicker than ever.


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