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Vetrix® BioSIS Technology

Providing resistance to infection, long term strength, and site specific healing

Order NowDownload BioSIS® Informational Brochure

At Vetrix, our goal is to help you help your patients by providing them with effective, industry-leading care. We do this by providing resources created by experts as well as innovative veterinary products. One of our most popular products is our BioSIS ECM Technology. Keep reading to learn more about how it works and how to get the best results. 

BioSIS Technology Surgical Applications

First things first—where can you utilize this technology in your practice? A few common surgical applications include:

  • Gastrointestinal soft tissue repair;
  • Thoracic wall repair;
  • Body wall and hernia repair;
  • Degloving injuries;
  • Mass removals;
  • Alternative to skin grafts.

Our BioSIS Technology provides a natural scaffold that works with and encourages your patient’s natural healing processes. Where other products inhibit these processes with foreign material, BioSIS works seamlessly with the patient’s own natural tissue repair. 

BioSIS is easy to use, inexpensive, and ensures that your patient heals with resistance to infection and no enhanced inflammatory response. The result is a natural repair with equal strength to that of their natural tissue. 

About Vetrix BioSIS Technology

Vetrix BioSIS ECM Technology is an extracellular matrix that combines the innate attributes of nature with the precision of science to enable the body to heal itself. It is an acellular biomaterial that does not encapsulate when surgically implanted—but is gradually remodeled, leaving behind organized and healthy tissue. The body’s tissue begins remodeling at the surgical site while BioSIS maintains the needed tissue support. When implanted, BioSIS Technology acts as a scaffold into which the patient’s cells migrate and integrate. The patient’s cells lay down their own collagen, which matures over time to form strong and permanent tissue repair—without leaving behind permanent foreign material. BioSIS is a collagen matrix, and therefore, the device is gradually replaced as the patient’s tissue gradually turns over in a natural state of self-renewal.

How It Works

Vetrix BioSIS ECM Technology supports tissue repair and results in remodeled, functional tissue without leading to encapsulation, premature breakdown of the material, calcification, or tissue erosion that can be caused by synthetic materials.

Signaling the Body

Unlike synthetic materials or some other biologic grafts, Vetrix products provide structure for healthy tissue to grow across and incorporate into the extracellular matrix. The result is completely remodeled, strong, fully vascularized tissue where damaged tissue once existed.

Enabling Complete Remodeling

Ideally, a biomaterial should produce a permanent repair without leaving behind a permanent material. Vetrix products facilitate this type of remodeling. Following implantation, the site-specific remodeled tissue displays similar physiologic and morphologic characteristics as the native tissue. During the healing process, Vetrix products are replaced by the body’s native tissue—developing into a permanent repair without the long-term presence of a foreign body.

Providing Resistance to Infection

For a biomaterial to repair a complex and contaminated tissue defect, it must be able to allow host defenses to fend off infection. Because Vetrix products structurally facilitate angiogenesis and rapid remodeling, they allow the body’s own defense mechanisms to react and respond to any potential infection.

Providing Long-term Strength

Vetrix BioSIS Technology is remarkably strong, and maintains the needed structural support to replicate the patient’s natural movement. Functioning as normal tissue, until the proper tissue has been restored, is vital to the differentiation of integrating patient cells.

Getting the Best Results with BioSIS Technology

BioSIS is designed to shorten healing times as well as provide resistance to infection and no additional inflammatory response. Like with most technologies, however, there are best practices you should adhere to in order to get these results. 

Blood Flow

Blood flow is crucial to the success of your healing process. Using the horizontal mattress technique allows for the scaffold to connect to numerous blood supply points. Fixing the graft in this way results in increased blood flow to the wound site. 

Bandages

When you’re changing your patient’s bandages, exercise caution. Keeping the matrix in place is very important. Using a non-adherent bandage will make this much easier!

In addition to being careful with bandages, it’s also important to bandage correctly. You’ll want to allow for as much mobility in your patient as possible—while not leaving any of the wound site open to the elements. Mobility encourages blood flow, which, as mentioned above, is crucial. 

Avoid Inflammation

While our BioSIS Technology naturally does not enhance inflammatory response, avoiding inflammation should still be top of mind. With a larger wound, perforating the BioSIS scaffold might be necessary to reduce the amount of fluid and dried blood that accumulates around the site.

Hugh Worsham, D.V.M

In less than two months the entire exposed cannon bone was covered with healthy granulation tissue and skin regeneration was underway. Because of the quick healing time, no bone death (sequestrum) occurred, which was the most pressing issue with Trigger’s injuries.

This has been a unique learning experience for me.

 

Vetrix is a world supplier of innovative veterinary products. With our technology, veterinarians are able to provide exceptional and progressive treatment to their patients. What’s our secret? Our technology harnesses the natural capabilities of the animal’s existing cells by providing a biological scaffold in which progenitor cells can embed. 

By merging the body’s natural healing process with advanced regenerative medicine, you’re able to provide superior care to your patients. Read on for more information about our BioSIS ECM Technology, and how it can help your practice. 

BioSIS ECM Technology: The Basics

To put it simply, BioSIS is a collagen matrix. This allows for the device, once applied to the patient, to gradually disappear as the patient’s organic tissue turns over in a natural state of self-renewal. The patient’s cells lay down their own collagen, resulting in strong (and permanent) tissue repair. One of the best benefits of this technology is that this process allows for no foreign material to be left behind once the healing is complete. 

How BioSIS Works with the Body

Essentially our BioSIS ECM Technology acts as a scaffold—providing much-needed support while the body goes through its natural healing process. After healing is complete, the patient is left with healthy, strong, and natural tissue. 

Instead of synthetic materials or other kinds of biological grafts, BioSIS encourages healthy tissue growth across its extracellular matrix. Your patient’s damaged tissue becomes strong, fully vascularized tissue. 

Because BioSIS works so seamlessly with the patient’s natural healing process, it’s also great at fighting off infection. It structurally facilitates angiogenesis and rapid remodeling, meaning it allows the body’s own defense mechanisms to do what they do best. 

What Sets BioSIS Apart from Other Products?

There’s a good reason why BioSIS works so well with patients’ natural tissue. BioSIS ECM Technology is not chemically stripped during processing. This means that it’s able to provide the most natural environment possible for native cells to migrate across and grow new vascularized tissue. Most other, similar products are treated with harsh chemicals or radiation—forcing them to lose that naturally occurring scaffold on which cells grow. 

Although natural and not treated with chemicals, BioSIS is remarkably strong. It provides the necessary support to mimic a patient’s natural movement. In simple terms, it acts as the patient’s organic tissue—until the actual organic tissue can regenerate and replace it. 

Vetrix: Your Partner in Veterinary Technology

At Vetrix, we have a lot of pride. We take pride in our technologies, our service, and our ability to help veterinarians all over the world provide the best possible care to their patients. We’re the leading provider of veterinary regenerative medicine for a reason. Our attention to detail shows not only in the quality of our products, but also in the consistency and delivery of those products. 

If you’re interested in learning more about BioSIS ECM Technology—or any of our other industry-leading products—get in touch with us. We’ll be happy to answer any and all of your questions! 

Order Now Download BioSIS® Informational Brochure

Remodel. Regrow. Restore.



SIGNALING THE BODY

Unlike synthetic materials or some other biologic grafts, Vetrix® products provide structure for healthy tissue to grow across and incorporate into the extracellular matrix. The result is completely remodeled, strong, fully vascularized tissue where damaged tissue once existed.

ENABLING COMPLETE REMODELING 

Ideally, a biomaterial should produce a permanent repair without leaving behind a permanent material. Vetrix® products facilitate this type of remodeling. Following implantation, the site-specific remodeled tissue displays similar physiologic and morphologic characteristics as the native tissue. During the healing process, Vetrix® products are replaced by the body’s native tissue—developing into a permanent repair without the long-term presence of a foreign body.

PROVIDING RESISTANCE TO INFECTION

For a biomaterial to repair a complex and contaminated tissue defect, it must be able to allow host defenses to fend off infection. Because Vetrix® products structurally facilitate angiogenesis and rapid remodeling, they allow the body’s own defense mechanisms to react and respond to any potential infection.

PROVIDING LONG TERM STRENGTH

Vetrix® BioSIS is remarkably strong, and maintains the needed structural support to replicate the patient’s natural movement. Functioning as normal tissue, until the proper tissue has been restored, is vital to the differentiation of integrating patient cells.

Order Now Download BioSIS® Informational Brochure

Frequently Asked Questions

Vetrix® BioSIS is derived from a porcine source, and it has not been chemically stripped in its processing. This leaves the extracellular matrix (ECM) and other naturally occurring properties intact. It provides a natural environment for native cells to migrate across and grow new vascularized tissue. Many competitive products are treated harshly with chemicals or radiation. They lose the naturally occurring scaffold, retained in our product, on which cells grow.

It is a naturally occurring extracellular matrix or biologic graft. This product should not be referred to as a dressing.

There is a smooth side or mucosal side, and a slightly rough side or serosal side. There is no clinical evidence that orientation plays a role in the migration of cells across or into the material.

YES!

BioSIS Frequently Asked Questions