Bandage with a non-adherent dressing, and carefully change the bandage.
BioSIS works by providing a scaffold that is eventually replaced by organized healthy tissue. As cells migrate into the graft, they will lay down their own collagen matrix, and begin to replace the BioSIS graft. Across the wound, BioSIS is resorbed at different rates. This is extremely important to know because as we change the bandaging, we want to leave as much of the remaining matrix intact as possible. Using a non-adherent bandage, and changing the bandage delicately, allows the remaining portions of the graft to stay in place.
Additionally, as the graft is incorporated into the wound, it will turn caramel colored. This typically happens within the first 6-10 days of implantation. DO NOT SCRAPE THIS OFF. It is often tempting to thoroughly clean the wound within the first week, however, it is imperative to leave this remaining matrix in place to ensure the best healing results. Simply irrigate with saline, and cover with another non-adherent bandage.