Revolutionizing Canine Corneal Ulcer Repair: Freeze-Dried Amniotic Membrane Grafts in Veterinary Ophthalmology

Deep melting corneal ulcers in dogs can present a rapid and devastating progression of ocular disease, often threatening the structural integrity of the eye and leading to potential vision loss or enucleation. Traditional repair methods, while effective, can involve significant tissue manipulation or lengthy healing periods. However, a 2025 study by Lengellé and colleagues highlights a promising advancement in the use of freeze-dried amniotic membrane (FD-AM) for surgical repair of these severe corneal injuries .

A Breakthrough in Canine Ophthalmic Surgery

The study examined 20 eyes from 15 dogs and 5 cats, all suffering from deep melting corneal ulcers that compromised at least 50% of stromal depth. These ulcers were surgically treated using Vetrix freeze-dried amniotic membrane grafts, known for their biocompatibility, structural support, and anti-inflammatory properties.

Importantly, the FD-AM used in this study was prehydrated and sutured directly to the corneal defect. In cases with significant stromal loss, multiple layers were applied to restore the corneal contour. To protect the graft and support healing, a conjunctival pedicle flap was also used in every case.

Impressive Clinical Outcomes

The clinical results were remarkable:

  • 90% success rate, with 18 of 20 eyes achieving successful structural and functional healing.

  • The two cases that were not visual had suffered from preexisting KCS.

  • The majority of dogs regained good visual function and showed minimal to no corneal scarring.

Furthermore, no complications associated with the FD-AM itself were reported. These findings demonstrate that freeze-dried amniotic membrane is not only effective but also a safe and readily available grafting option for urgent corneal reconstruction.

Why Freeze-Dried Amniotic Membrane Matters

FD-AM offers several advantages over fresh or cryopreserved alternatives:

  • Long shelf life without the need for freezing or refrigeration.

  • Easy storage and handling, allowing immediate use in emergency ocular surgeries.

  • Biological activity retained through specialized processing, promoting natural cell regeneration and reducing inflammation.

For veterinarians managing corneal ulcers in dogs—particularly those that are rapidly progressing or associated with matrix metalloproteinase activity—FD-AM provides a versatile solution that can be integrated into general or specialty ophthalmic practice.

The Role of Vetrix in Advancing Eye Care

At Vetrix, we are committed to bringing regenerative solutions to veterinary surgery. Our freeze-dried amniotic membrane products are engineered to meet the high demands of surgical reliability and biological compatibility. This study further supports the value of FD-AM in improving outcomes for canine patients facing serious ocular threats.

As the field of veterinary ophthalmology evolves, incorporating biologic scaffolds like FD-AM into routine practice not only enhances healing but may also prevent permanent vision loss—aligning with our mission to improve animal health through innovation.

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Brachycephalic Dog Breeds and Corneal Ulcers: Recognizing the Signs and Protecting Your Dog’s Vision

Brachycephalic dog breeds—those with short noses and flat faces—are undeniably adorable, but their unique anatomy makes them prone to a variety of health issues, including serious eye problems. One of the most common and concerning conditions they face is corneal ulcers, which, if left untreated, can lead to severe pain, vision loss, and even eye removal.

Understanding how to spot corneal ulcers early and seeking prompt treatment, such as Vetrix EyeQ Amniotic Eye Drops, can help prevent complications and protect your dog’s eyesight.

Brachycephalic Dog Breeds at Risk

Brachycephalic breeds have bulging eyes, shallow eye sockets, and reduced eyelid coverage, making them highly susceptible to corneal ulcers. Some of the most commonly affected breeds include:

  • French Bulldogs
  • English Bulldogs
  • Pugs
  • Boston Terriers
  • Shih Tzus
  • Pekingese

Because their eyes protrude, they are more likely to experience injuries from debris, rough play, or even rubbing their faces on surfaces. Additionally, some brachycephalic dogs struggle with incomplete blinking, which prevents their corneas from staying properly lubricated, increasing the risk of ulcers.

How to Spot Corneal Ulcers in Your Dog

Corneal ulcers can develop quickly, so it’s crucial to recognize the early signs. If your dog is showing any of these symptoms, consult a veterinarian immediately:

✔️ Excessive blinking or squinting
✔️ Redness in the eye
✔️ Watery or thick eye discharge
✔️ Cloudiness or a visible spot on the eye
✔️ Rubbing the eye with paws or against furniture
✔️ Reluctance to open the eye in bright light

Since brachycephalic breeds already have compromised eye health, even minor eye irritation can quickly escalate into a serious ulcer.

The Dangers of Untreated Corneal Ulcers

Ignoring a corneal ulcer can have devastating consequences for your pet. Without proper treatment, ulcers can:

❌ Deepen into the eye, leading to perforation and irreversible damage
❌ Cause extreme pain, affecting your dog’s quality of life
❌ Result in blindness, especially if the cornea ruptures
❌ Require expensive surgery, with procedures costing up to $2,000 per eye
❌ Lead to eye removal (enucleation) in severe cases

The best way to protect your dog’s vision is early intervention. Treating corneal ulcers as soon as they appear can prevent long-term damage and reduce the risk of surgical intervention.

Vetrix EyeQ: A Cutting-Edge Solution for Corneal Ulcers

When it comes to treating corneal ulcers, Vetrix EyeQ Amniotic Eye Drops is a great solution for early treatment.

Why Choose EyeQ for Your Dog?

✔️ Prevents Vision Loss – Supports natural healing, reducing the risk of blindness
✔️ Reduces Pain – Soothes irritation and discomfort associated with ulcers
✔️ Speeds Up Healing – Encourages faster corneal repair with regenerative properties
✔️ Avoids Costly Surgery – Helps prevent the need for expensive and invasive procedures

Unlike traditional treatments that only address symptoms, EyeQ enhances corneal regeneration, making it a powerful tool for veterinarians treating brachycephalic dogs with eye issues.

Protect Your Dog’s Eyes Before It’s Too Late

Brachycephalic breeds are prone to eye injuries and corneal ulcers, but with early detection and the right treatment, you can keep your pet comfortable and protect their vision. By watching for symptoms and using Vetrix EyeQ Amniotic Eye Drops as an early intervention, you can avoid painful complications, expensive surgeries, and potential blindness.

If your dog is showing signs of an eye ulcer, don’t wait—consult your veterinarian today and ask about Vetrix EyeQ.

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The Benefits of Amnion in Veterinary Medicine: Introducing EyeQ Equine Amniotic Eye Drops

Amnion-based therapies are gaining recognition in veterinary medicine for their remarkable ability to promote natural healing and reduce inflammation. These biologic products, derived from the amniotic membrane, provide veterinarians with innovative treatment options for a range of conditions. At Vetrix, our mission is to harness the regenerative power of amnion to elevate patient care, which is why we are excited to introduce EyeQ Equine Amniotic Eye Drops, designed specifically for horses.

In this article, we’ll explore the unique benefits of amnion in veterinary applications, discuss how EyeQ Equine stands out from other eye care products, and explain why it’s becoming a go-to solution for veterinarians treating equine eye issues.

Understanding the Power of Amnion in Veterinary Medicine

Amnion, the innermost layer of the placenta, has long been known for its regenerative properties. This tissue is rich in growth factors, cytokines, and anti-inflammatory molecules, which can encourage natural healing and minimize scarring. These qualities make amnion an invaluable asset in veterinary medicine, especially for delicate tissues like the eye.

Benefits of Amnion:

  1. Promotes Natural Healing: Amniotic membrane tissue is packed with growth factors that stimulate cellular repair, helping to restore tissue without the need for synthetic compounds.
  2. Reduces Inflammation: Amnion’s natural anti-inflammatory properties help alleviate pain and swelling, making it ideal for conditions where inflammation is a primary concern.
  3. Minimizes Scarring: For areas that are prone to scarring, such as the cornea, amnion can reduce fibrotic tissue formation, promoting clear vision and faster recovery.
  4. Antimicrobial Properties: Studies have shown that amnion has inherent antimicrobial activity, which helps protect wounds from infection.

Introducing EyeQ Equine Amniotic Eye Drops

Vetrix’s EyeQ Equine Amniotic Eye Drops were developed to address the specific needs of horses, which often differ from those of small animals. Horses are particularly prone to eye injuries and infections due to their outdoor environments and larger, more exposed eyes. Conventional eye drops may provide temporary relief, but they often fail to address the underlying inflammation and potential for scarring that can lead to chronic issues.

EyeQ Equine combines the regenerative power of amnion with a formulation tailored to equine physiology. It’s designed to be applied as needed to support healing in cases of corneal ulcers, conjunctivitis, and other eye injuries or irritations. Key differentiators of EyeQ Equine include:

  • Higher Concentration of Amniotic Components: EyeQ Equine has an enhanced concentration of growth factors and anti-inflammatory proteins, addressing the unique healing needs of equine eyes.
  • Species-Specific Formulation: Unlike standard EyeQ drops, which are tailored for small animal use, EyeQ Equine is optimized for horses, coming in an easy to use glass vial. You simply add 10mL of saline, shake then draw up the needed amount in a syringe. This allows easy application through a SPL system.

With EyeQ Equine, veterinarians can now offer a biologic solution that leverages the full potential of amnion for equine patients. This product represents a significant advancement over traditional treatments, providing both immediate relief and long-term healing benefits.

How EyeQ Equine Differs from Standard EyeQ Drops

While the standard EyeQ Amniotic Eye Drops have already become a trusted option in small animal ophthalmic care, EyeQ Equine takes amnion therapy to the next level for equine-specific needs.

  1. Equine EyeQ is delivered in a glass vial for easy use with a SPL.
  2. Equine EyeQ Amnion is finer than the small animal version, allowing it to pass easily through a SPL.

For veterinarians, this means a more effective, easy-to-use option that simplifies care routines and improves healing outcomes in equine patients.

Conditions Treated by EyeQ Equine Amniotic Eye Drops

EyeQ Equine is an excellent choice for treating Corneal Ulcers: Horses are prone to corneal ulcers from injuries or foreign objects. EyeQ Equine’s regenerative properties support healing, reducing the risk of scarring that can impair vision.

The Vetrix Difference in Regenerative Medicine

At Vetrix, we are committed to providing veterinarians with top-quality, research-backed regenerative solutions. EyeQ Equine is a testament to our dedication to advancing veterinary care, giving veterinarians a natural and highly effective way to address equine eye conditions.

By leveraging the healing potential of EyeQ Equine Amniotic Eye Drops, Veterinarians can feel confident treating their toughest cases.

Conclusion

For equine patients, EyeQ Equine Amniotic Eye Drops represent a groundbreaking approach to eye care. Backed by the regenerative power of amnion, this product helps veterinarians treat a wide range of eye conditions more effectively, promoting natural healing while minimizing the risk of infection and scarring. With species-specific formulation and a commitment to quality, Vetrix continues to lead the way in regenerative medicine for veterinary use.

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EyeQ amniotic Eye Drops further Regenerative medicine that is Affordable, Effective, and Easy-to-Use

Vetrix®: Leading the Way in Veterinary Regenerative Medicine with EyeQ Amniotic Eye Drops

In the world of veterinary medicine, innovation is crucial for ensuring that pets receive the best possible care. Vetrix® has long been a pioneer in the field of regenerative medicine, offering solutions that help veterinarians provide advanced treatments to their patients. Among our groundbreaking products, EyeQ Amniotic Eye Drops stand out as a testament to our commitment to quality, consistency, and cutting-edge care.

The Power of Amnion in Veterinary Care

Regenerative medicine is revolutionizing treatment options in both human and veterinary fields, and at the forefront of this transformation is amnion. The amniotic membrane, which forms part of the placenta during pregnancy, is packed with natural anti-inflammatory and regenerative properties. Harnessing the healing power of amnion, EyeQ Amniotic Eye Drops represent an innovative approach to treating various ocular conditions in animals.

EyeQ is designed to provide superior therapeutic benefits, promoting faster healing while reducing discomfort and inflammation. This groundbreaking formula makes it easier for veterinarians to offer a higher standard of care, improving outcomes for pets suffering from a range of eye conditions.

Elevating Care with EyeQ Amniotic Eye Drops

EyeQ Amniotic Eye Drops are a game-changer for veterinarians. Unlike traditional eye treatments, EyeQ takes full advantage of the regenerative properties of amnion. This unique product works by encouraging natural tissue regeneration, promoting faster healing of damaged ocular tissues.

Our EyeQ Amniotic Eye Drops offer an affordable, easy-to-use solution that enables veterinarians to treat more patients with a higher level of care. Whether you’re dealing with corneal ulcers, chronic dry eye, or post-surgical recovery, EyeQ ensures consistent and effective results across a broad spectrum of cases.

Why Choose Vetrix®?

At Vetrix®, we understand that quality and consistency are critical in veterinary care. That’s why we are committed to maintaining the highest standards in the development and production of our regenerative medicine products.

Our mission is simple: to empower veterinarians with the best tools available so they can provide exceptional care for their patients. With EyeQ Amniotic Eye Drops, veterinarians can confidently offer innovative, non-invasive treatments that significantly improve patient outcomes, all while keeping the treatment process convenient and affordable.

Affordable, Effective, and Easy-to-Use

One of the key benefits of EyeQ Amniotic Eye Drops is how simple they are to administer. We know that ease of use is essential for busy veterinary practices, and EyeQ makes it easier than ever to incorporate cutting-edge regenerative medicine into everyday care.

Moreover, EyeQ is a cost-effective solution. By offering a treatment that delivers superior results without breaking the bank, veterinarians can provide enhanced care to a broader range of patients. It’s a win-win for both practitioners and their furry patients.

The Future of Veterinary Medicine is Regenerative

At Vetrix®, we believe that the future of veterinary care lies in regenerative medicine. EyeQ Amniotic Eye Drops are just one example of how harnessing the power of amnion can lead to revolutionary advancements in treatment. As we continue to innovate and expand our product line, we remain dedicated to providing veterinarians with the tools they need to deliver exceptional care.

If you’re a veterinarian looking for a reliable, affordable, and highly effective solution for treating ocular conditions, EyeQ Amniotic Eye Drops from Vetrix® is the answer. Experience the difference that regenerative medicine can make in your practice and witness how EyeQ can help you provide the highest level of care for your patients.

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KCS in Dogs: Symptoms, Treatment, and More

amniotic eye dropsKeratoconjunctivitis sicca (KCS), often referred to as dry eye, is inflammation of the cornea and surrounding tissues due to inadequate production of tears. Tears are necessary to lubricate the cornea and remove debris or any infectious agents that come in contact with the eye. The tear film is a mixture of mucus, fatty liquid, and water.

Symptoms of KCS in Dogs

Most dogs with KCS will have painful, red, irritated eyes. Squinting and excessive blinking often signal a dog’s mom or dad to get their pet to a veterinary professional for treatment. Additionally, KCS often includes symptoms of thick, yellowish mucous discharge due to the lack of the watery component of the tear film. Corneal ulceration may also be present.

Patients with chronic cases of KCS often present with a history of conjunctivitis, eye injuries, and ulcers. Corneal scarring, hyperpigmentation, usually occurs with cases of KCS and looks like a dark film covering the dog’s eye.

Is A Dog More Likely to Contract KCS Because of Their Breed?

KCS most commonly affects middle-aged to older dogs. It’s more likely to be seen in the following breeds:

  • American Cocker Spaniel
  • Bloodhound
  • Boston Terrier
  • Cavalier King Charles Spaniel
  • English Bulldog
  • English Springer Spaniel
  • Lhasa Apso
  • Miniature Schnauzer
  • Pekingese
  • Pug
  • Samoyed
  • Shih Tzu
  • Yorkshire Terrier

Both eyes are typically affected in dogs with KCS, but one eye may appear worse.

Treatment of KCS in Dogs

There are two main objectives when treating KCS in dogs:

  • Stimulate tear production
  • Replace the tear film and protect the cornea

Tear film replacement and tear production stimulants are often used in combination first. However, Veterinarians manage most KCS cases in dogs with a combination of tear stimulants, tear substitutes, antibiotics, and anti-inflammatories. Surgery for KCS is reserved for dogs who do not respond to medication and are experiencing persistent pain. Secondary bacterial conjunctivitis is common in dogs with KCS due to debris accumulation and a lack of natural antimicrobial tear properties. Additionally, patients often experience much discomfort and pain with KCS and the ulceration that often accompanies it. Anti-inflammatory and antibiotic combinations are helpful for improving comfort and diminishing corneal opacities.

Vetrix created a solution for veterinarians, EyeQ Amniotic Eye Drops, to deliver natural antimicrobial and anti-inflammatory components alongside traditional therapies when treating KCS. EyeQ is an easy-to-use, non-surgical option for treating corneal defects and ulcers and keeping a dog as comfortable as possible throughout treatment. What’s more, EyeQ allows easy administration for veterinarians and dog owners alike. The medicine comes in a convenient dropper bottle and is available to veterinary professionals in 6-pack, 12-pack, and 24-pack options.

Provide The Best Care for Your Dog

Getting attached to dogs you see regularly (even if they aren’t your dog) is easy. We can all agree that when it comes to treating dogs with KCS, all we want is for the animal to get better. If you’re a Vet who intends to provide the best care for the KCS and ulcer cases you see in dogs, try out a 6-pack of EyeQ for yourself. If you’re not completely satisfied, Vetrix will work with you to return your purchase.

Order Now

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Corneal Uclers in Pets: Symptoms, Treatment & More

Eye Drops for Pets

The cornea, which is transparent in normal conditions, covers the front part of the eye and allows light to pass into the eye. The eyelids cover the cornea to protect it from trauma and help spread tears (essential to corneal health). Most corneal ulcers in pets result from trauma, such as scratches, dry eye, eyelid anomalies, or abrasions due to foreign objects in the eye.

Corneal Ulcer Symptoms

A corneal ulcer is an open wound within the cornea. Ulcers are painful for pets; most heal within a week if appropriately treated. However, if a corneal ulcer becomes infected, it can quickly turn into a deep wound. The most common symptoms of corneal ulcers to watch for in pets include the following:

  • Squinting
  • Redness
  • Ocular discharge
  • Excessive Blinking
  • Excessive tears
  • Swelling
  • The eye appears cloudy

If the ulcer results from a tear deficiency, you may see a thick discharge resembling mucous that ranges from transparent to white, green, or yellow. If you are a cat parent, a dog parent, or a veterinarian who wants to provide helpful materials to your patients of specific pets, please read the following information:

Corneal Ulcer Diagnosis

Any of the signs mentioned above should prompt pet parents to make an appointment with their veterinarian. The vet will use several diagnostic methods at the appointment to accurately diagnose the ulcer. Once the affected eye (or eyes) are examined, your vet will discuss the best possible treatment plan.

Corneal Ulcer Treatment

How a pet’s corneal ulcer is treated is determined by the type of animal in need of treatment and the type of ulcer they are being treated for. Treating corneal ulcers properly from the start is crucial to ensuring a pet’s comfort and healing without further complications or damage to its vision. Mild corneal ulcers will usually heal on their own in 3-7 days, depending on the size of the ulcer. While healing, vets may recommend a treatment plan to prevent further damage or cornea infections. 

Here are common treatments used to treat corneal ulcers in pets:

  • Antibiotic eye drops or ointments to prevent infections
  • Pain medication to keep your pet comfortable
  • An E-collar to prevent your pet from rubbing and allow the cornea to heal properly
  • Regenerative eye drops 

Regenerative eye drops, like Vetrix EyeQ Eye Drops, are a simple way to provide regenerative care for a pet’s eye. Regenerative medicine works with the body’s natural abilities to heal itself. EyeQ Eye Drops deliver natural anti-microbial and anti-inflammatory components to aid in healing corneal ulcers in pets. 

As part of the healing process, a follow-up care plan must be issued and adhered to by the patient. Pets should continue treatment with all prescribed medications until a veterinarian says the ulcer has fully healed.

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Here’s Why Not to Underestimate Dry Eye in Dogs

What Is Dry Eye in Dogs?

The simplified explanation for dry eye is an inadequate production of tears. However, the condition is so much more complicated than that definition would lead you to believe. The eye is a complex ecosystem containing germ-fighting cells and pH balanced glands.

A dog’s eye is covered by what’s called a tear film: a thin, complex fluid that covers the eye. To keep the eye healthy, tears are produced to cover the cornea, washing away debris and harmful bacteria.

Dry eye isn’t just a condition in dogs; humans can suffer from it, as well. However, the symptoms and severity are not as pronounced.

How to Spot Dry Eye

Flat-faced breeds of dogs (shih tzus, pugs, Boston terriers, etc.) are more susceptible to dry eye than others. If you’re attending to a dog in that breed category, you’ll want to do a thorough check of their eyes and talk with their owner to make sure the patient isn’t exhibiting any irritable behavior when it comes to their eyes. Dogs are most likely to develop dry eyes between 4-6 weeks old, but this condition can still appear at any age. 

There are a few signs and symptoms you can be on the lookout for caused by dry eye in dogs. The first symptoms you may notice are red eyes and mucoid discharge. This is usually due to the lack of tears produced to adequately coat the eye and keep it free of irritants. It can also be due to underproduction of a specific type of high-quality tear. The former cause is the most common.

Other signs include pawing at the eyes due to pain and excessive blinking to keep the eyes closed.

Like pannus in dogs, dry eye is an immune-related condition in that it is caused by the dog’s own immune system attacking a part of its body. What it thinks is a foreign invader, is actually functioning as it normally should. In this case, the immune system attacks and shuts down the lacrimal glands—the structures that produce tears. If left untreated, dry eye can lead to painful ulcers that can rupture or pigment build-up causing permanent blindness.

Less common causes include medications, like oral antibiotics containing sulfonamide, and genetic factors that cause abnormally small glands.

What to Do About Dry Eye

Once dry eye is confirmed by a Schirmer tear test or using special stains on the cornea, there are a couple of different treatment options. Like many conditions, one of the most important factors when it comes to treatment for dry eye in dogs is early detection. But no matter how early the detection, treatment is lifelong.

The most common and effective treatments today are medicated drops or ointment that goes directly on the affected eye. By stimulating the lacrimal glands to produce more tears or start producing tears again, the drops or ointment should be able to give some relief to your patient.

Vetrix is a trusted resource for veterinary practices and the devoted owners they continually serve. Browse other topics of interest that provide you with much-needed information.

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A Primer on Pannus in Dogs

What Is Pannus in Dogs?

The scientific name for pannus is Chronic Superficial Keratitis (CSK). It’s an autoimmune disease that affects the cornea part of the eye. Pannus is most commonly found in breeds such as German shepherds, border collies, and greyhounds but is not limited to these breeds only.

CSK occurs when the cornea is damaged by UV light rays. The dog’s immune system sends small blood vessels to the cornea in an attempt to repair the damage. Since corneas do not have blood vessels, the immune system assumes these vessels are a foreign invader and attack the corneal tissue and vessels.

The attack on corneal tissue leads to the formation of scar tissue. If this goes untreated, it will lead to severe visual impairment and, ultimately, blindness. While there’s no cure for pannus, it can be managed and treated in a way that allows your patient to continue living a full and active life.

Symptoms of Pannus

One symptom of pannus is the visual presentation of the blood vessels sent to heal the UV light damage. Reddening at the 3 o’clock and 9 o’clock hours of the pupil becomes visible when this happens. Changes in pigmentation, cloudiness, and blood vessels begin to form on the outer edges of the cornea and move inward.

Further progression of this autoimmune disease leads to discharge, thickening, and loss of pigmentation in the third eyelid of dogs. At this point, the pannus has progressed to a subclass of CSK called plasmoma.

Management and Treatment Options

Pannus can be easily confused with other eye issues in dogs, such as dry eye or corneal ulcers, so it’s important to be sure of your diagnosis before prescribing a treatment plan. If you confirm pannus in your patient, warn the owner about being especially vigilant with UV light exposure if they live at higher altitudes or are commonly exposed to such environments. If you know this is an issue for your patient, you may want to suggest to their owner a pair of UV dog goggles for when they’re outside or moving to an area of lower altitude.

When caught in its early stages, pannus is very manageable and unlikely to cause much disruption to the daily life of the pet and owner. Stopping the formation of blood vessels is key in this process. The most common treatment options are medical-grade eye drops, such as dexamethasone, prednisolone, or cyclosporine. Over time, application frequency will likely decrease if the owner continues to be cautious about UV light exposure.

However, in severe cases, sometimes surgery is necessary to remove the excess scar tissue. Otherwise, visual impairment to the point of blindness is a possibility.

Vetrix is a trusted resource for veterinary practices and the devoted owners they serve. See other topics of interest that provide you with the information you need. 

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SEQUESTRUM REMOVAL BIOSIS PLUS+

Dr. Enry Garcia da Silva, DVM, DACVO of VCA Aurora Animal Hospital – 4YOMN DSH Sequestrum Removal BioSIS Plus+

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