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BioSIS as a Biological Scaffold

BioSIS is revolutionizing the way veterinarians are able to care for seriously wounded patients. Due to its framework and ability to attract cells, BioSIS may shorten healing time and ensure organized tissue regrowth in the damaged area. Good blood flow is key to using the BioSIS method successfully. Read on to discover how to get the best results when using this method of wound care in your patients.

Use the Horizontal Mattress Technique

Proper blood flow is essential to successfully using BioSIS as a biological scaffold. Using the horizontal mattress technique to fixate the graft encourages blood flow to the wound site, by connecting to many points of blood supply. This also enables you to slide the edges of the implant under the undermined tissue edges and allows for further connectivity to the patient’s healthy blood supply.

Throughout BioSIS insertion, you can also use “tacking” to apply independent sutures and ensure it’s secure and flush against the wound.

Perforate the BioSIS Scaffold if Necessary

To avoid inflammation, fenestration may be necessary. This usually only applies to larger wounds to keep cells and other fluids from accumulating between the BioSIS scaffold and healing flesh. It is also helpful in preventing a hematoma from forming.

One major threat to the success of this procedure is dried blood. This generates inflammation, which is crucial to limit throughout the healing process. Stoppage of blood flow can prevent cells from evenly attaching to the scaffold and deter the healing process.

Keep the Matrix in Place

Once cells begin to lay their own collagen matrix, it’s important to be extremely careful when changing bandages. As the patient’s own cells take over the BioSIS graft, it will be resorbed at different rates—not all at once. When changing bandages, it’s imperative that as much of the extracellular matrix from the implant be left intact to continue healing. Using a non-adherent bandage to dress the wound will help you to change it more easily.

Within the first 6-10 days of post-operative recovery, the wound will turn caramel-colored as the damaged tissue is replaced and repaired. Instead of thoroughly cleaning the wound and scraping off this pigment, simply irrigate with saline and apply another non-adherent bandage. This way, all of the graft is resorbed and healing is even across the entire contusion.

Allow/Encourage Wound Site Mobility

When bandaging the patient, allow for as much mobility as possible while still covering the entirety of the wound site. Mobility encourages blood flow which, as we mentioned earlier, is essential to the success of this method of healing.

Based on extensive research, we’ve found that mobility increases the rate at which the healing occurs and makes for a better off healing process overall. This is because the cells attaching themselves to the scaffold receive their direction from the surrounding matrix’s blood flow. If blood flow is weak or immobile, the cells will have no direction to follow. Just remember, form follows function.
We’d love to answer any questions you may have about this technique. Contact us to learn more or tell us how you’ve been able to help your patients using BioSIS technology. You can also visit here for more blogs on topics like this.

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Amniotic Ocular Discs and Grafts for Veterinarians

We now offer shelf-stable, decellularized amniotic membrane discs for the purpose of healing your patients’ ocular lifespan. We are excited to announce this new, cost-effective way to help repair essential tissues. 

Our EyeQ ocular discs have been proven to maintain strength, are easy to handle, and are comfortable for patients—giving you the flexibility to choose the most effective device for each procedure and per each individual’s unique needs. From a general standpoint, once the surgery is over, patients typically recover quite well, displaying routine behavior soon thereafter. 

Learn More About Its Success 

Amniotic tissue has been used as a surgical graft for a variety of successful ophthalmic surgeries, operative procedures, and in a number of eye disorders. These include corneal epithelial surface reconstruction surgery, partial limbal stem cell deficiency, corneal perforations and ulcers, acute inflammation, and many other severe, time-sensitive ocular disorders. 

The science behind amniotic membrane material is unique as its composition contains five kinds of collagen types: I, III, IV, V, and VII. Each collagen type serves a different purpose in the healing process and, when all of these are combined together, something special occurs.

Furthermore, the amniotic membrane is composed of extracellular matrix structures, which exhibit a makeup of grouped, specialized proteins, including fibronectin, laminins, proteoglycans, and glycosaminoglycans. This is significant because even a single layer of these cells can transform the body (in this case, the eyes) to be more collagen-rich. In this case, as the mesenchyme attaches to the chorion. 

Finally, we have found that the amniotic membrane contains many essential healing properties that benefit its growth factors. These factors include epidermal growth, transforming growth-beta, fibroblast growth, and platelet-derived growth.

Contact Us Today for Your Ocular Discs! 

This information overload was brought to you by Vetrix, Inc., a specialist in veterinary technological services. We are here to help you help your patients. Head back to our website to get more information, contact us, or to download our brochure about EyeQ amniotic discs. Plus, keep coming back to our blog for more industry-leading products and services. We are a resource to help your practice do right by your patients!

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Vetrix’s Healion Amniotic Wound Matrix

Treating wounds is part of everyday life in a veterinary practice. Vets encounter different types of injury daily from accidental wounds to surgical or recurring wounds, all requiring different types of wound management according to the patient. 

Supporting wounds and offering the best in regenerative technology can ensure that the healing time is cut down and the patient is on the right track. The Vetrix Healion amniotic wound matrix is paving the way for regenerative medicine. 

What Is the Healion Amniotic Wound Matrix? 

The wound matrix developed by Vetrix is a regenerative decellularized amniotic membrane; the material consists of collagen and an extracellular matrix. The matrix is rich in proteins, laminins, and proteoglycans. 

The matrix stimulates healing and growth of the dermis while ensuring that wounds heal faster and better with fewer complications. Naturally occurring growth factors within the matrix stimulate the regeneration of the epidermis and offer protection at the wound site. 

The Benefits Of Vetrix Wound Matrix

There are many benefits to using an amniotic wound matrix. Reducing your patient’s healing time can significantly reduce the risk of infection and complications that could arise from prolonged wound management. 

  • Setting the right environment – The Vetrix Healion creates the perfect healing environment. The amniotic matrix sets the healing environment right, allowing tissues to repair effectively and efficiently. 
  • Sterile – The sterile applicator ensures that you are not inserting anything into the wound that could compromise healing. 
  • Ease of use – Healion is packaged in a unique dispenser; the ergonomic design is created for ease of use and allows hard-to-treat areas to be accessed with ease.
  • Cost-effective – Faster healing wounds cost less. The Vetrix matrix is a cost-effective solution for your practice’s wound management needs. By reducing the need for patients to return, they save on pricey wound maintenance trips to your practice. 
  • Single application – The wound matrix is efficient enough to be used in a single application in most cases. More complex wounds might require an additional application of the Vetrix Healion; however, a single application is needed for most injuries. 
  • Open wound care – The matrix modulates inflammation and stimulates a healing environment. 

Investing in wound care can resolve some of the most complicated wounds, allowing animals to return to their regular lives sooner, reducing stress and frustration for veterinary practices, owners, and the animals themselves. 

If you have any concerns or want any additional information – get in touch with Vetrix; we are happy to answer any questions and walk you through the Healion Wound Matrix.

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