Revolutionizing Veterinary Wound Care with Healion: A Case Study in Regenerative Medicine

In the ever-evolving field of veterinary medicine, innovative products like Healion Amniotic Wound Matrix are setting new standards for wound healing. By utilizing the powerful properties of amnion, Healion provides veterinarians with a reliable and effective tool for treating complex wounds, enhancing the natural healing process. This blog post will explore the remarkable healing journey of a turtle, showcasing the benefits of Healion in veterinary wound care.

The Role of Amnion in Regenerative Medicine

Amnion, the innermost layer of the placenta, is packed with growth factors, anti-inflammatory properties, and essential proteins that are crucial in wound healing. The Healion Amniotic Wound Matrix, derived from this unique tissue, is delivered in a powdered form, making it easy to apply. This product promotes rapid tissue regeneration, reduces inflammation, and provides a bioscaffold for new cells to grow, making it an invaluable solution in regenerative medicine.

Case Study: A Turtle’s Fast-Track to Recovery

Dr. Garry Innocent, a veterinarian at All Species 24hr Clinic in Alpharetta, GA, encountered an exotic patient with a severe head injury. The turtle had been scalped, leaving no tissue to facilitate traditional wound closure. Faced with this daunting challenge, Dr. Innocent turned to Healion Amniotic Wound Matrix.

Within 24-36 hours of applying Healion, the results were nothing short of extraordinary. The wound began healing rapidly, showing organized, healthy tissue growth. Dr. Innocent expressed his satisfaction, noting that Healion was simple to apply and did not lead to further complications, unlike traditional wound treatments which sometimes cause additional trauma.

For a case where minimal tissue was available and the delicate nature of the patient complicated suturing, Healion’s trauma-free application was the perfect solution. The turtle’s speedy recovery demonstrates the effectiveness of this regenerative wound care tool across different species.

Why Healion Is Essential for Veterinarians

Healion’s amnion-based matrix provides a safe, versatile, and easy-to-use solution for a wide range of wound types, including surgical wounds, trauma injuries, and ulcers. Its unique properties not only accelerate healing but also minimize scarring, making it a preferred choice in complex cases where traditional methods fall short.

The ability to promote natural tissue regeneration without causing additional trauma makes Healion indispensable for treating patients where suturing isn’t viable or safe. Additionally, its application is simple, reducing the stress for both veterinarian and patient, whether treating small, exotic animals or common household pets.

Conclusion

Healion Amniotic Wound Matrix is revolutionizing the way veterinarians approach wound healing. By leveraging the regenerative properties of amnion, it offers an effective solution for complex wounds that are difficult to close or heal. In the case of Dr. Innocent’s turtle, Healion proved its ability to facilitate fast, trauma-free healing in a delicate patient, underscoring its versatility and power as a regenerative medicine product. For veterinarians seeking reliable and advanced wound care options, Healion is a must-have in the medical toolkit.

Small dog on a vet’s tableBite wounds are one of the most common reasons dogs see their veterinarians. If a dog is bitten or gets into a fight with another dog, this is what needs to happen first:

  1. As the dog’s owner, stay calm. Panic will only make the situation worse.
  2. Don’t get between your dog and the other dog(s) to break up the fight. You could also get bit in the process.
  3. Focus on getting your dog away from the other dog. A loud clap or another distracting sound may help get your dog’s attention so you can call or signal him to you.
  4. Don’t scream at the other dog, as this could make the situation feel even more threatening to the dogs.
  5. Ask the other dog owner (if present) if their dog is up to date on their vaccines. If the pet owner isn’t present or the other dog involved is a stray, try to get pictures at the very least.
  6. Once your dog is safely away from the dog who bit him, contact your vet immediately or head to your nearest emergency animal hospital.

Why Do Dogs Bite?

Biting is often part of play for puppies. In adult dogs, multiple motives or causes for biting can stem from competitive issues or reactions to perceived threats. Additionally, several factors influence the severity of a dog bite and the health risk it can pose to a pet. This is why seeing your veterinarian as quickly as possible after your dog has experienced a bite is a good idea.

Treating Bite Wounds in Dogs

Dog bites can cause significant injury to the skin and soft tissues. A dog’s teeth and jaws are powerful; a bite wound can result in torn muscles and skin. Not all bite wounds are big, though. Just because a bite wound is small doesn’t mean it isn’t a cause for concern. Minor bites can heal themselves quickly but, in doing so, can trap bacteria in the wound that can result in an abscess.

Infections are the primary concern for any dog bite, but other serious issues can develop if not treated properly. Typically, a vet will examine and thoroughly clean the bite wound and then provide a broad-spectrum antibiotic to help fight infection and prevent further complications with the wound site. Or, the vet can use Vetrix’s Healion Amniotic Wound Matrix as part of their patient’s bite wound treatment plan. 

Healion is a decellularized amniotic membrane supplied in fine, dry, sterilized white powder form for veterinary use. Healion amniotic wound matrix leverages the natural healing properties of the amnion to modulate inflammation and create an environment conducive to rapid cell migration.

You apply it to the wound site and appropriately bandage it to create a sterile healing environment. The bite should be re-examined every 4-5 days, and a single application is usually sufficient.

How To Help A Dog Heal After A Bite

As a vet, your priority is preventing your patient’s bite wound from getting infected. Start treating bite wounds with a fast and effective treatment option that makes patients and clients happy. Add Healion to your medical toolkit today. Order now.

BioSIS wound dressing photolarge copyAny veterinarian worth their salt knows that providing superior wound care treatment starts with assessing the overall stability of the animal. Once the patient is stable, the next step is administering first aid for the wound as soon as safely possible. Your treatment should follow the fundamentals of debridement, infection or inflammation control, and moisture balance. Success depends on taking the correct approach and deciding whether to manage the wound as open or closed.

Before considering surgery, veterinarians looking for a more effective wound treatment should explore Healion Amniotic Matrix. The solution is an easy-to-use, sterilized powder that promotes the healing of wound sites.

Provide Superior Wound Care with Healion Wound Matrix

When choosing wound care solutions for your patients, protecting the wound sight from further contamination and trauma is often a top concern. This is where Healion Wound Matrix can help, especially in situations where a wound cannot or should not be closed. Healion is a decellularized amniotic membrane supplied in fine, dry, sterilized white powder form for veterinary use. It leverages the natural healing properties of amnion to modulate inflammation and create an environment conducive to rapid cell migration. All you must do is puff the solution onto the wound bed and cover it with a non-adherent bandage.

Once administered, and as we touched on at the beginning of this post, it’s advised you consider the following four things while caring for your wound patient:

  1. Giving the wound proper support
  2. Maintaining proper moisture levels
  3. Mitigating infection risk
  4. The phases of wound healing

If these four factors aren’t considered when bandaging and monitoring your patient, you might not see the healing you expect. (Remember pain management throughout the phases of recovery, too.)

Healion Wound Matrix serves as a wound care solution where open wound management or delayed wound closure is the best course of action for the patient. Healion is uniquely designed to enable veterinarians to provide superior wound care treatment and is indicated for the management of wounds, including:

 

  • Partial wounds
  • Full-thickness wounds
  • Surgical wounds
  • Trauma wounds
  • Draining wounds

Do You Want to Provide Superior Wound Care Treatment?

It’s time to join top veterinarians using the best regenerative wound care technology and provide your patients with faster and more effective treatment options. Healion Wound Matrix provides an ideal healing environment and flexibility in treating both acute and chronic wounds, and it’s affordable.

Healion is cost-effective and packaged to fit procedural needs. Learn about Healion Wound Matrix pricing (available in 6-pack, 12-pack, and 24-pack options).

Veterinary Neurology Vetrix

When a patient has a wound that’s too big to close on its own or a wound that becomes chronic and doesn’t heal by itself, treatment with a skin graft may be beneficial in obtaining wound closure. Skin grafts help quickly and effectively restore function and provide better cosmetic results than other treatment options. Additionally, skin grafts protect from infections and parasites. The Vetrix BioSIS Technology we provide is a regenerative medicine beneficial in remodeling, regrowing, and repairing wounds encountered in the veterinary field.

Two Common Skin Graft Procedures in Veterinary Medicine

When it comes to common household pets, veterinarians are often most likely to perform one of the following types of skin grafts when necessary for wound treatment:

  • Total Skin Graft (or Full-thickness skin graft): This skin graft includes the epidermis and dermis. It involves removing a piece of skin and the fat from the underside of the skin. This grafting procedure requires the donor site to have enough surrounding loose skin so the incision can be closed.
  • Partial Thickness Skin Graft (or Split-thickness skin graft): This skin graft involves shaving a thin layer of skin, 0.2 to 0.4mm, off the donor site. The cutting plane of this graft remains above the hair follicles so that no hair will grow from this skin graft. The donor site will heal independently and doesn’t require closure, but it may be more painful than a total skin graft because the exposed nerve endings will need time to heal. It’s typically used in burn victims with limited normal skin for grafting.

Veterinarians will guide their patients on the best skin graft option for their particular wound.

Treating Skin Grafts With Regenerative Veterinary Medicine

Once it’s been determined that a pet needs a skin graft to heal a wound, consider a regenerative medicine solution as part of your treatment. Unlike synthetic materials or other biological grafts, Vetrix Technology provides a structure for healthy tissue to grow across and incorporate into the extracellular matrix, resulting in wholly remodeled, vital, and fully vascularized tissues. During the healing process, Vetrix BioSIS is replaced with the body’s native tissue, developing into a permanent repair without the long-term presence of a foreign body. After healing is complete, patients are left with healthy, natural tissue.

BioSIS is a great regenerative medicine solution for skin grafts because it facilitates angiogenesis and rapid remodeling, allowing the body’s defense mechanisms to react and respond to any potential infection. It promotes safe and sterile healing of the wound.

Download the BioSIS Informational Brochure to learn more about this technology and how it can aid in healing skin graft patients.

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We know you want to give your patients the best care there is. From diet and nutrition to coat care to wound care, you want to feel confident that you’re up to speed on the latest technology and products. This can be difficult when there’s so much information out there. When it comes to wound care, you can trust Vetrix to deliver the most accurate information and help you take the best care of your patients. Keep reading to learn how Vetrix BioSIS is superior to polypropylene mesh.

The Inflammatory Response

In a study done on rats, researchers compared Marlex (MX), a polypropylene mesh, to small intestine submucosa (BioSIS), a non-cross-linked collagen matrix, to repair the abdominal wall. When implanted, MX caused an immediate and intense inflammatory response in the rats. However, early-stage tensile strength was increased. The inflammatory response may be attributed to poor tissue compatibility, but it’s important to note that such a strong inflammatory response can lead to increased adhesion formation, bladder dysfunction, bowel obstruction, as well as other maladies.

The inflammatory response with BioSIS was present, however, the response was less than that of the MX. 

Adhesion Density

BioSIS implants showed thicker density than MX implants within the first 14 days of extraction, however, this subsided after the 14-day mark passed. This density was attributed to fluid accumulation. While MX increased less in thickness during the initial 14 days, this perBioSISted throughout the rest of the 90 days. At the 30 day mark, the adhesion grade was greater in the MX treated extractions.

The extent of adhesion formation was the same in both groups up until 90 days when BioSIS-implanted rats showed more adhesions. So while BioSIS implants produced more adhesions after 90 days, they were less dense than the MX implant adhesions.

Collagen Production

As mentioned earlier, BioSIS produced a lower inflammatory response than MX. This was indicative of the type of collagen forming. The collagen production in the BioSIS explants was slower than that of MX. However, at the end of four weeks, 90% of the BioSIS implants had degraded and were replaced by macrophages and stronger scar tissue. This shows that the novel collagen produced was superior to that of the MX implant.

The issue of the BioSIS being weaker than MX can be overcome by increasing the number of layers in the BioSIS implant. And although the tensile strength was weaker at one month, by the end of the 90 days, the strength of the materials was comparable.

Why BioSIS Is Superior to Polypropylene Mesh

In summary, BioSIS implants produced less dense adhesions, a significantly lower inflammatory response, and a more architecturally stable collagen matrix for the formation of stronger scar tissue.

Have questions about Vetrix BioSIS? We’d love to hear from you and give you more information. Contact us today!  And if you’d like to read more about interesting topics like this, check out our blog page.

When it comes to veterinary medicine, wound treatment could be deemed as one of the most common tasks. Dogs and cats are often more prone to traumatic wounds than illness and disease. When treating a wound, the end goal is always to restore the tissue in a way that will support the animal in getting back to its prior function. 

However, the road the veterinarian takes to get from point A to point B can vary tremendously depending on the specifics. Here, we will take a closer look at veterinary wound management principles, including some of the basics of wound care.

The 7 Steps of Effective Veterinary Wound Management

From classification to aftercare monitoring, every step in the wound management process plays a role in the effectiveness of treatment.

1. Wound Classification

The first step of wound management is classification to determine how taking care of the wound should be addressed. Wounds are classified differently according to how long the wound has been present and the degree of contamination. Wounds can be:

  • Clean -Surgical wound made under sanitary conditions or with an aseptic technique
  • Clean-contaminated – Less than 6 hours old, no major contamination but some risks for infection
  • Contaminated – Older than 6 hours, presence of foreign contamination
  • Dirty – An older wound, infected, usually more than 12 hours old

The second important step in classifying the wound is determining what stage of healing the wound is in.

Stages of Wound Healing

Wound healing generally occurs in three distinct phases:

  • Inflammation/Debridement – Onsets at time of injury, typically lasting between three and five days. Blood vessels minimize to control bleeding. Clots form via thrombin, platelets, and coagulation. Blood flow then increases, which causes immediate inflammation and swelling and white blood cells to initiate wound debridement. Growth factors are produced to kick off the healing process.
  • Angiogenesis/Repair  – Granulation tissue formation begins through collagen synthesis. Myofibroblasts are stimulated, which helps contract and help the wound opening start to close. Epithelial cells begin the proliferation process across the wound bed. The process continues from five days all the way through to maturation and remodeling.
  • Apoptosis/Skin Remodeling –  Through about four weeks after the initial tissue trauma, collagen synthesis supports the ongoing maturation of new skin cells and tissues. This process gradually slows, but the wound may continue to mature for as long as 18 months.

Of course, not every wound will follow the expected process during healing. Chronic wounds, for example, don’t progress as they should from one stage of healing to the next, which is why the wounds often persist for far longer and are exceptionally hard to treat. Oftentimes, a non-healing wound will experience some disruption in the healing process that prevents the formation of new tissue.

*Federal Law requires that our products may only be sold to a licensed veterinarian or veterinary hospital.

2. Wound Lavage (Flushing)

Dirty wounds are more likely to become infected wounds. Wound lavage is performed on the open wound with an antiseptic, nontoxic fluid like a diluted antiseptic. This flushing process is done to wash away and hopefully eradicate visible debris like hair and dirt, but also to reduce the levels of bacteria that may already be forming in the tissue that could promote wound infection. 

Common wound flushing techniques are typically done with a 35mL syringe and should be performed with around 8lb per square inch of pressure to adequately clean but not damage the healthy tissue. However, a secondary benefit of lavage is to get a better look at the wound edges and the wound itself.

3. Wound Debridement

Debridement is done to remove necrotic tissue (tissue damage) to preserve healthy tissue and promote healthy granulation tissue. Debridement is a critical step in the process because the tissue that is not healthy can get in the way of making the right decision on how to further address wound treatment and wound closure. Sometimes, the presence of necrotic tissue layers can cause delayed primary closure when closure could otherwise be possible.

Mechanical debridement is more non-selective in nature. This form of debridement removes necrotic tissue and potentially vital tissue that would support healing. Therefore, mechanical efforts are normally kept to a minimum.

4. Closing the Wound

With a wound classified, lavaged, and debrided, the doctor must determine if wound closure is necessary or if it would be best to proceed with open wound management. Wound closure may be done with staples, sutures, or surgical adhesives, and even the cleanest wounds may not be immediately closed. 

During this type of closure, the individual layers of skin are pulled closer to minimize the amount of open space. Wounds that have a minimal degree of contamination and clearly defined wound edges may be closed between 24 and 72 hours.

If a wound is severely infected or otherwise contaminated, primary wound closure may not be an option. The closure will be delayed and the open wound is managed until the tissue looks healthy and proper healing is more likely. If a delayed wound closure happens more than five days after the injury, the procedure is known as secondary closure.

5. Open Wound Management

Second-intention healing (open wound management) is a process that takes place if a wound cannot be closed. Some situations when open wound management will be necessary include if the wound is too severely infected or there has been a substantial loss of healthy skin, which would make proper closure impossible until more tissue forms.

When a wound is left open, ongoing debridement is possible and repeated bandaging or dressing is a must. The objectives with an open wound are clear cut; the wound must be properly handled to prevent infection and promote healing in the most efficient and painless way possible.

Open wounds can be difficult to manage in the long term because numerous factors can get in the way of the healing process that is actually beyond the caregiver’s control. For example, older dogs and cats or animals with skin disease can be slow healers. Therefore, the steps taken with bandage changes and dressing, as well as ongoing debridement and treatment of the wound surface, are critically important.

*Federal Law requires that our products may only be sold to a licensed veterinarian or veterinary hospital.

6. Bandaging the Wound

In order to encourage wound healing, there are four primary things that need to be considered when bandaging a wound:

  • You must give the wound the support it needs for proper healing
  • You must maintain proper moisture levels in and around the wound
  • You must take steps to thwarts risks of infections
  • You must consider the multiple phases of wound healing

If any of the four areas are not properly addressed when dressing the wound, wound closure and healing can be impeded.

Wound dressings consist of three layers:

  • Primary layer – In direct contact with the surface of the wound, prevents wound contamination, and is either adherent or non-adherent; can be either moistened with wound healing products for moist wound healing or dry
  • Secondary layer – Offers both absorption and compression to protect the underlying primary layer and the wound; usually some type of rolled gauze 
  • Tertiary layer – Keeps other layers stabilized with a slight bit of pressure; usually elasticized wrap or porous tape

Negative-pressure wound therapy and tie-over bandages may also be used. For example, tie-over bandages may involve using umbilical tape to keep banging in place.

The traditional bandaging or dressing techniques involve using wet-to-dry dressings, which essentially means the dressing starts out as wet and then transitions to dry once granulation tissue starts to develop. The initial granulation tissue can be especially prone to damage with a wet dressing. However, a more modern concept is moist wound healing, which essentially combines a debridement solution with the dressing that supports the health of white blood cells and promotes granulation tissue formation.

7. Pain Management and Monitoring

Once an animal’s wound has been properly addressed, ongoing pain management and monitoring are important until the wound is almost completely healed. If the wound is causing discomfort, the animal will be more likely to lick and gnaw at the opening, which can impede the natural process of the healing tissue and prolong the time it takes as the wound heals. For a traumatic wound, an animal may even be sedated for several days simply to prevent distress.

If a wound does not close on its own fully or leaves a severe impression, reconstructive surgery using skin and tissue grafts or some level of surgical intervention may be necessary later to fully restore the function of the wounded area.

Innovations in Non-Surgical Wound Treatment

One of the more innovative ways wounds are addressed in modern veterinary medicine involves taking a non-surgical approach and using regenerative solutions. While small animal surgery for wound repair can be effective, it also comes along with a number of unavoidable risks for the animal and excessive costs for the pet owner.

Even standard wound management can be especially time-consuming and leaves the animal at risk of wound infection because of the slow healing process. Therefore, efforts have been taken scientifically to create better treatments that help regenerate the tissue surrounding a wound to quicken healing. For example, Healion Amniotic Particulate Matrix helps to modulate inflammation and create an environment that supports the rapid mitigation of new cells. Healion utilizes innate attributes of amniotic membrane to promote healing.

To find out more about Healion Amniotic Particulate Matrix, be sure to download the brochure from the Vetrix website.

*Federal Law requires that our products may only be sold to a licensed veterinarian or veterinary hospital

Caring for and treating patients with chronic wounds can sometimes be frustrating and discouraging. You so desperately want to give them the best wound care possible and see them live their lives to the fullest, but nothing seems to offer a permanent solution. You may be able to improve your results with the BioSIS method.

Using Porcine Small Intestinal Submucosa (SIS) for Wound Care

Researchers say that using porcine SIS to treat chronic wounds has improved healing time and permanency. Due to its makeup, an acellular, biological extracellular matrix (ECM), porcine small intestinal submucosa draws in the host’s cells to attach and multiply. This aids in quicker, more permanent healing.

Growth compounds like collagen, elastin, glycosaminoglycans, and proteoglycans help with the healing process. And it’s not just one cell that’s attracted to the matrix. Porcine SIS attracts numerous cell types for a healthy, diverse layer formation. Since it takes more than growth factors to aid in the healing process, it’s fortunate that SIS has been found to decrease matrix metalloproteinases (MMP) activity. These endogenous proteolytic enzyme levels usually rise with chronic wounds.

Even better, the mechanical properties of multi-layer SIS are stronger and degrade slower as opposed to single-layer SIS. Pertaining to the repair of different kinds of wound types, these two SIS products provide flexibility when choosing a biologically-active ECM.

1-Layer VS. 3-Layer SIS

When choosing between 1-layer SIS and 3-layer SIS, studies show a thicker matrix may be preferable. One study done in diabetic mice showed the 3-layer SIS didn’t require application as frequently as the 1-layer matrix. Where both SIS layers were applied to full-thickness wounds on the day of wounding and three days later, the thicker matrix showed larger sections of unincorporated layers—meaning there was still significant space in the matrix for cells to mitigate.

This is good to know for patients that may have owners who live farther away and travel a greater distance for appointments or cannot afford frequent applications.

More Reasons to Consider the SIS Method

Besides reducing MMP levels, you may also want to consider the SIS method for wound care because it contains proteins that foster cell attachment and growth factor binding sites, sequester matrix-degrading enzymes, and enhance cellular filtration into damaged tissue. In addition to these positive effects, it also supports new blood vessel growth, which is vital to wound recovery.

Overall, small intestinal submucosa has been found to not only increase healing in wounds but also the rate at which the wounds recover compared to the standard of wound care.
If you’d like to further discuss this method of wound care or have any questions, please contact us. We would be happy to speak with you! And if you’d like to read more on topics like this, visit our blog page.

Any successful wound management can be achieved through the correct application process and products. Managing wounds for your patients can be made easy in a variety of ways, and we have provided you with a handful of tips to make it smoother and more successful for your practice. 

#1: Wound Irrigation 

This can be effectively determined by the amount of solution or product used on the patient, rather than the kind of solution or product. There is no exact formula or measurement that fits each patient, which is why each patient should be treated uniquely and individually. 

#2: Irrigation Pressure

By applying pressure to the site, bacteria can easily be removed from the wound and not cause more damage to the surrounding tissue. 

#3: Debridement 

If there are any foreign objects located in the wound or in the surrounding areas, assess the necrotic tissue. Evaluate if it should be removed, but—if the tissue viability is questionable—then wait and reassess in the coming days. 

#4: Topical Agents 

Topical creams or our Healion Amniotic Particulate Matrix can be applied at the right time to the wound, and can play an essential role in the healing process. 

#5: Contact Bandages 

After the topical agents or the healion matrix are applied, cover the site with a bandage to ensure a protected healing environment. 

Healing Process 

The ultimate goal of restoration and healing for the epithelial surface can take time, and often has different phases. 

The first phase is the inflammation and debridement phase, which lasts three to five days after the wound has occurred. By draining the site, killing bacteria, getting rid of debris, and applying topical creams, the site will settle down and the healing process can truly start. 

The second phase occurs from day four to 12, generally speaking. During this time, the wound closes, and tissue is regenerated. 

The last phase is the maturation phase, which begins when collagen orients stress lines. This phase doesn’t have a specific timeline due to the different kinds of wounds, with some deeper or more severe than others. The strength of the skin can be healed by about 10% at two weeks, 25% by four weeks, and 80% by a couple of months.

Contact Us

Contact us today to talk with one of our representatives about the ways you can implement successful and productive healing in your veterinary practice. Managing your patients’ wounds is a quintessential aspect of your practice, therefore it should not be neglected. Head to our website today to learn more!